Stephens N L
Can J Physiol Pharmacol. 1977 Aug;55(4):828-32. doi: 10.1139/y77-111.
We have shown in the past that hypoxia impairs contractile activity in tracheal smooth muscle (TSM). This was associated with partial uncoupling of mitochondria. It remained to be determined whether these changes were reversible. The TSM model was felt to be superior to the isolated mitochondria since it was likely to be free from artefacts inherent in procedures involving homogenisation and extraction. We report here that the oxygen uptake rates of the isolated, mechanically active TSM were increased in the posthypoxia recovery period when compared with the prehypoxia active muscle. Mechanical recovery was complete.
我们过去已经表明，缺氧会损害气管平滑肌（TSM）的收缩活性。这与线粒体的部分解偶联有关。这些变化是否可逆仍有待确定。TSM模型被认为优于分离的线粒体，因为它可能没有涉及匀浆和提取的程序中固有的假象。我们在此报告，与缺氧前的活性肌肉相比，缺氧后恢复期分离的、具有机械活性的TSM的氧摄取率增加。机械恢复是完全的。
