Hisatomi K, Isomura T, Aoyagi S
Second Department of Surgery, Faculty of Medicine, Kagoshima University, Japan.
Thorac Cardiovasc Surg. 1996 Dec;44(6):296-9. doi: 10.1055/s-2007-1012040.
We measured the levels of creatine kinase-MB (CK-MB) and myosin light chain (MLCI) in 86 patients after double valve replacement to investigate whether measurement of the postoperative changes in myosin could be useful in patients undergoing valve surgery. In particular, we compared the postoperative levels of CK-MB and MLCI with the occurrence of postoperative low cardiac output syndrome (LOS). In both groups of patients (group I: without LOS, group II: with LOS), the peak CK-MB level was observed on postoperative day 1, and the peak myosin level on postoperative day 5. No significant differences were found in the postoperative levels of CK-MB between the two groups. On the other hand, a significant difference in the levels of MLCI on postoperative day 5 was observed (p < 0.05). Our results also showed that the peak level of CK-MB significantly correlated with the cardiopulmonary bypass time (r = 0.50), while the peak level of MLCI was significantly correlated with the postoperative cardiac index (r = -0.45). Our retrospective findings suggest that postoperative measurement of MLCI may be useful for estimating the postoperative myocardial impairment after valve surgery.
我们检测了86例双瓣置换术后患者的肌酸激酶同工酶（CK-MB）和肌球蛋白轻链（MLCI）水平，以研究肌球蛋白术后变化的检测对瓣膜手术患者是否有用。特别是，我们将CK-MB和MLCI的术后水平与术后低心排血量综合征（LOS）的发生情况进行了比较。在两组患者中（第一组：无LOS，第二组：有LOS），CK-MB水平在术后第1天达到峰值，肌球蛋白水平在术后第5天达到峰值。两组之间术后CK-MB水平无显著差异。另一方面，术后第5天MLCI水平存在显著差异（p<0.05）。我们的结果还表明，CK-MB的峰值水平与体外循环时间显著相关（r = 0.50），而MLCI的峰值水平与术后心脏指数显著相关（r = -0.45）。我们的回顾性研究结果表明，术后检测MLCI可能有助于评估瓣膜手术后的心肌损伤。
