人神经母细胞瘤细胞中与化学诱导分化相关的中期因子表达改变。
Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells.
作者信息
Koshizawa S H, Matsumura T, Kadono Y, Sawada T, Kadomatsu K, Muramatsu H, Muramatsu T
机构信息
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyoku, Japan.
出版信息
Cancer Lett. 1997 Jan 1;111(1-2):117-25. doi: 10.1016/s0304-3835(96)04526-0.
Midkine (MK), a neurotrophic polypeptide of which expression is developmentally regulated in embryogenesis, is expressed in malignant tumor tissues including neuroblastoma (NB). A retinoic acid analogue, E5166, and dibutyryl cyclic AMP (dbcAMP) are known to induce differentiation in NB cells. This study showed that MK mRNA expression increased in association with differentiation by E5166, but not by dbcAMP in SK-N-SH and KP-N-RTBM1 human NB cell lines. We concluded that MK could be an important factor in differentiation of NB cells, and further, that there could be at least two pathways in differentiation of NB cells at molecular mechanism.
中期因子（MK）是一种神经营养多肽，其表达在胚胎发生过程中受到发育调控，在包括神经母细胞瘤（NB）在内的恶性肿瘤组织中表达。已知一种视黄酸类似物E5166和二丁酰环磷腺苷（dbcAMP）可诱导NB细胞分化。本研究表明，在SK-N-SH和KP-N-RTBM1人NB细胞系中，MK mRNA表达随E5166诱导的分化而增加，但不随dbcAMP诱导的分化而增加。我们得出结论，MK可能是NB细胞分化中的一个重要因素，此外，在NB细胞分化的分子机制中可能至少存在两条途径。
Zotero 插件