体内致死剂量辐射对肿瘤核膜脂质微粘度的影响。
The effect of lethal doses of radiation in vivo on the lipid microviscosity of tumor nuclear membranes.
作者信息
Mal'tseva E L, Pal'mina N P
机构信息
Russian Academy of Sciences, Institute of Biochemical Physics, Moscow, Russia.
出版信息
Appl Radiat Isot. 1996 Nov-Dec;47(11-12):1683-7. doi: 10.1016/s0969-8043(96)00194-7.
The changes in the microviscosity of the nuclear membranes of tumor and liver cells of tumor hosts with developing Erlich ascites carcinoma at different times after irradiation of lethal dose has been studied by spin probe method. Using two iminoxyl radicals localized in various lipid regions, it was shown that the character and degree of changes in microviscosity, estimated from rotational correlation time for spin probes, indicate the different response to irradiation of liver and tumor cells.
采用自旋探针法研究了在致死剂量照射后不同时间，患艾氏腹水癌的宿主的肿瘤细胞和肝细胞的核膜微粘度变化。使用定位在不同脂质区域的两种亚胺氧基自由基，结果表明，根据自旋探针的旋转相关时间估算的微粘度变化特征和程度，表明肝细胞和肿瘤细胞对辐射的反应不同。
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