Jaffe N, Buell D, Cassady J R, Traggis D, Weinstein H
Cancer Treat Rep. 1977 Sep;61(6):1001-7.
Childhood non-Hodgkin's lymphoma is characterized by a high incidence of leukemic transformation. A retrospective analysis of this incidence in 227 children is provided. In an attempt to identify factors associated with this phenomenon, the extent of disease in 30 recently diagnosed patients was determined by means of a modified Ann Arbor staging system. Concurrently, the staging system was utilized for the delivery of a new treatment program: chemotherapy was administered to all patients, and those with stage I and II disease also received radiation therapy to sites of bulk tumor. An overall disease-free survival of 75% was achieved. No patient with stage I disease converted to acute leukemia. The data suggest that the major utility of staging is the delineation of anatomic sites of bulk tumor. The chemotherapeutic program utilized in these patients is outlined.
儿童非霍奇金淋巴瘤的特点是白血病转化发生率高。本文对227例儿童的这一发生率进行了回顾性分析。为了确定与这一现象相关的因素，采用改良的Ann Arbor分期系统对30例新诊断患者的疾病范围进行了评估。同时，该分期系统被用于实施一项新的治疗方案：所有患者均接受化疗，I期和II期疾病患者还接受了大块肿瘤部位的放射治疗。总体无病生存率达到了75%。没有I期疾病患者转化为急性白血病。数据表明，分期的主要作用是勾勒出大块肿瘤的解剖部位。文中概述了这些患者所采用的化疗方案。
