Baraldi P G, Cacciari B, Romagnoli R, Spalluto G, Garuti L, Roberti M, Pani A, Perra G, Scintu F, Pinna N, Musiu C, La Colla P
Anticancer Drug Des. 1996 Dec;11(8):597-609.
Uracil derivatives bearing substituted or unsubstituted vinyl groups at position C6 and alkyl- or arylthio groups at position C5 were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds were active against HIV-1. However, some of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations. The maximum potency of antiproliferative activity correlates with the presence of unsubstituted vinyl groups and alkyl- or arylthio substituents.
