转化生长因子-α（TGF-α）表达在乳腺癌中的预后意义

Prognostic significance of TGF-alpha expression in breast cancer.

作者信息

Auvinen P K, Lipponen P K, Kataja V V, Johansson R T, Syrjänen K J

机构信息

Department of Pathology, University of Kuopio, Finland.

出版信息

Acta Oncol. 1996;35(8):995-8. doi: 10.3109/02841869609100717.

DOI:10.3109/02841869609100717

PMID:9023384

Abstract

A series of breast cancer biopsies from 204 women were analysed immunohistochemically for the expression of transforming growth factor alpha (TGF-alpha). Expression of TGF-alpha was intense in 119 cases (58%), weak in 63 (31%), and totally absent in 22 (11%) of the cases. No correlation was observed between the expression of TGF-alpha and tumour size, metastasis at diagnosis, histological type and grade, ER and PR status, DNA index, S-phase fraction or the expression of TGF-beta1 or beta2. However, the expression of TGF-alpha was significantly related to axillary lymph node metastasis and to low survival probability during the follow-up. These data support the earlier observations on the in vitro studies, suggesting that TGF-alpha most probably exerts an in vivo growth stimulation of female breast cancer cells.

摘要

对204名女性的一系列乳腺癌活检标本进行免疫组织化学分析，以检测转化生长因子α（TGF-α）的表达情况。119例（58%）病例中TGF-α表达强烈，63例（31%）表达较弱，22例（11%）病例中完全无表达。未观察到TGF-α表达与肿瘤大小、诊断时有无转移、组织学类型及分级、雌激素受体（ER）和孕激素受体（PR）状态、DNA指数、S期细胞比例或TGF-β1或β2表达之间存在相关性。然而，TGF-α的表达与腋窝淋巴结转移及随访期间低生存率显著相关。这些数据支持了早期体外研究的观察结果，提示TGF-α很可能在体内对女性乳腺癌细胞发挥生长刺激作用。