Hodgman M J, Martin T G, Krenzelok E P
Department of Emergency Medicine, St Joseph Hospital, Bangor, Maine, USA.
Hum Exp Toxicol. 1997 Jan;16(1):14-7. doi: 10.1177/0960327197016001031.
A number of novel serotonergic antidepressants have been introduced to clinical practice over the last decade. These medications are felt to be safe alternatives to the traditional tricyclic antidepressants and monoamine oxidase inhibitors, particularly in the overdose setting. Serious adverse reactions and drug interactions have been appreciated and fatalities have been reported. We describe the development of the serotonin syndrome in a 60 year old female on chronic tranylcypromine treatment following the inadvertent ingestion of a single dose of venlafaxine. Manifestations included and altered mental status that progressed to hyperthermia and coma. She recovered quickly and without complications. Health care providers and poison specialists need to be aware that this potentially serious syndrome can be precipitated by a single dose of a serotonin reuptake inhibitor in patients being treated with a monoamine oxidase inhibitor.
在过去十年中，多种新型血清素能抗抑郁药已应用于临床实践。这些药物被认为是传统三环类抗抑郁药和单胺氧化酶抑制剂的安全替代品，尤其是在过量用药的情况下。人们已经认识到其严重的不良反应和药物相互作用，并且已有死亡报告。我们描述了一名60岁女性在长期服用反苯环丙胺治疗期间，因意外单次服用文拉法辛后发生血清素综合征的情况。症状包括精神状态改变，进而发展为高热和昏迷。她恢复迅速且未出现并发症。医疗保健人员和中毒专家需要意识到，正在接受单胺氧化酶抑制剂治疗的患者，单次服用血清素再摄取抑制剂可能会引发这种潜在的严重综合征。
