Butt K I, Manabe M, Yaguchi H, Tsuboi R, Ogawa H
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
J Dermatol Sci. 1996 Dec;13(3):193-201. doi: 10.1016/s0923-1811(96)00534-8.
Epimorphin was originally identified as a mesenchymal cell surface-associated protein that modulates epithelial morphogenesis in embryonic skin and lung epithelia. A previous report which utilized embryonic mouse skin, showed that epimorphin was localized non-homogeneously in a region adjacent to the epidermis and in a mesenchymal cell condensation located in front of growing hair follicles. We report herein a further detailed localization of this protein in adult mouse skin using immunoelectron microscopy. Epimorphin was found to be localized on the undersurface of basal cells, in the cytoplasm of cell processes of fibroblasts, as well as on the plasma membrane of fibroblasts, endothelial cells, pericytes, perineurium and endomysium. Our present finding indicated that epimorphin is one of the factors involved in multiple biological functions in a variety of structures derived from various origins and that it is not a specific epithelial morphogenetic factor.
表皮形态发生素最初被鉴定为一种间充质细胞表面相关蛋白，它可调节胚胎皮肤和肺上皮中的上皮形态发生。先前一项利用胚胎小鼠皮肤的报告显示，表皮形态发生素在与表皮相邻的区域以及位于生长毛囊前方的间充质细胞凝聚物中呈非均匀分布。我们在此报告使用免疫电子显微镜对该蛋白在成年小鼠皮肤中的进一步详细定位。发现表皮形态发生素定位于基底细胞的下表面、成纤维细胞突起的细胞质中，以及成纤维细胞、内皮细胞、周细胞、神经束膜和肌内膜的质膜上。我们目前的发现表明，表皮形态发生素是参与多种来源的各种结构中多种生物学功能的因素之一，并且它不是一种特异性的上皮形态发生因子。
