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突触前烟碱型乙酰胆碱受体

Presynaptic nicotinic ACh receptors.

作者信息

Wonnacott S

机构信息

School of Biology and Biochemistry, University of Bath, UK.

出版信息

Trends Neurosci. 1997 Feb;20(2):92-8. doi: 10.1016/s0166-2236(96)10073-4.

DOI:10.1016/s0166-2236(96)10073-4
PMID:9023878
Abstract

Nicotinic ACh (nACh) receptors in the CNS are composed of a diverse array of subunits and have a range of pharmacological properties. However, despite the fact that they are ligand-gated cation channels, their physiological functions have not been determined. This has led to increased interest in presynaptic nACh receptors that act to modulate the release of transmitter from presynaptic terminals.

摘要

中枢神经系统中的烟碱型乙酰胆碱(nACh)受体由多种亚基组成,具有一系列药理特性。然而,尽管它们是配体门控阳离子通道,但其生理功能尚未确定。这使得人们对调节突触前终末递质释放的突触前nACh受体越来越感兴趣。

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