视网膜母细胞瘤蛋白在生长抑制和死亡保护中的作用

Retinoblastoma protein in growth suppression and death protection.

作者信息

Wang J Y

机构信息

Department of Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0347, USA.

出版信息

Curr Opin Genet Dev. 1997 Feb;7(1):39-45. doi: 10.1016/s0959-437x(97)80107-4.

DOI:10.1016/s0959-437x(97)80107-4

PMID:9024632

Abstract

Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RB has an active role in antagonizing the death response. How RB integrates its multiple functions into a tumor suppression program is still an open issue.

摘要

令人困惑的新信息表明我们对视网膜母细胞瘤蛋白（RB）的理解存在不足。RB与转录因子E2F似乎是协同作用的。RB-E2F相互作用对于生长抑制是必要的，但并不充分。与肿瘤抑制因子的身份不符的是，RB在拮抗死亡反应中发挥着积极作用。RB如何将其多种功能整合到肿瘤抑制程序中仍是一个悬而未决的问题。