Katz M E, McCormick F
Bayer Corporation, Pharmaceutical Division, 400 Morgan Lane, West HavenConnecticut, 06516 USA.
Curr Opin Genet Dev. 1997 Feb;7(1):75-9. doi: 10.1016/s0959-437x(97)80112-8.
Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effectors for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras binding proteins the biochemical and biological properties of which are poorly understood.
Ras蛋白通过与丝氨酸/苏氨酸激酶Raf直接结合来激活信号级联反应。它们还激活其他对充分的生物学活性至关重要的信号通路。这些通路的候选效应分子包括RalGDS和磷脂酰肌醇3'激酶，以及其他几种Ras结合蛋白，其生化和生物学特性尚不清楚。
