雌激素替代疗法与绝经后冠心病女性的运动表现

Estrogen replacement therapy and exercise performance in postmenopausal women with coronary artery disease.

作者信息

Sbarouni E, Kyriakides Z S, Nikolaou N, Kremastinos D T

机构信息

2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.

出版信息

Am J Cardiol. 1997 Jan 1;79(1):87-9. doi: 10.1016/s0002-9149(96)00685-6.

DOI:10.1016/s0002-9149(96)00685-6

PMID:9024746

Abstract

We treated 10 postmenopausal women with stable angina, positive exercise test, and documented coronary artery disease with oral conjugated equine estrogen (0.625 mg/day of Premarin) or placebo for 4 weeks, in random order, with crossover after a 4-week washout period. Exercise tests, performed after each treatment period while the patients were taking their usual antianginal drugs showed no differences; thus, short-term estrogen does not improve exercise-induced ischemia compared with placebo.

摘要

我们对10名患有稳定型心绞痛、运动试验阳性且有冠状动脉疾病记录的绝经后女性，随机给予口服结合马雌激素（Premarin，0.625毫克/天）或安慰剂，为期4周，之后经过4周的洗脱期进行交叉治疗。在每个治疗期结束后，患者服用常规抗心绞痛药物时进行运动试验，结果显示无差异；因此，与安慰剂相比，短期雌激素并不能改善运动诱发的心肌缺血。