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Liver disease in polyglandular autoimmune disease type one: clinicopathologic study of three patients and review of the literature.

作者信息

Goldstein N S, Rosenthal P, Sinatra F, Dehner L P

机构信息

Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073-6769, USA.

出版信息

Pediatr Pathol Lab Med. 1996 Jul-Aug;16(4):625-36.

PMID:9025859
Abstract

We report the findings from liver biopsies of three patients with polyglandular autoimmune disease type 1. The livers in two patients had histologic features of chronic hepatitis that eventuated in bridging fibrosis and cirrhosis over a period of several years. Nonspecific lobular and portal tract inflammation was present in the liver biopsy of the third patient. Although these patients did not have liver-specific autoantibodies, the liver disease in polyglandular autoimmune disease type 1 possibly represents an expression of autoimmune hepatitis.

摘要

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