Cohen M C, Kaschula R O, Sinclair-Smith C, Emms M, Drut R
Department of Pathology, Superiora Sor María Ludovica Children's Hospital, La Plata, Argentina.
Pediatr Pathol Lab Med. 1996 Sep-Oct;16(5):801-12.
Congenital melanocytic nevi are benign lesions present at birth and considered to be caused by a maldevelopment of the neural crest. The malignant potential of the congenital melanocytic nevi have been extensively addressed by several authors, and malignant melanoma is the most frequent neoplasm arising in these lesions. The present report describes two patients with congenital melanocytic nevi in which malignant melanoma with undifferentiated areas showing rhabdomyoblastic differentiation developed. The findings suggest that these mixed neoplasms may be recapitulating the differentiation potential of the ectomesenchyme-neural crest cells. We advocate the term "melanoblastoma" when referring to them.
先天性黑素细胞痣是出生时即存在的良性病变，被认为是由神经嵴发育异常引起的。先天性黑素细胞痣的恶性潜能已被多位作者广泛探讨，恶性黑色素瘤是这些病变中最常见的肿瘤。本报告描述了两名患有先天性黑素细胞痣的患者，其中发生了具有未分化区域且显示横纹肌母细胞分化的恶性黑色素瘤。这些发现表明，这些混合性肿瘤可能再现了外胚间充质 - 神经嵴细胞的分化潜能。我们建议在提及它们时使用“黑素母细胞瘤”这一术语。
