Amass S F, Wu C C, Clark L K
School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
J Vet Diagn Invest. 1996 Jan;8(1):64-7. doi: 10.1177/104063879600800110.
Seventy clinically normal 13-day-old crossbred pigs from 10 litters from a Streptococcus suis-infected herd were randomly assigned by litter and weight to 7 groups of 10 pigs each to determine whether different antibiotic regimens would eliminate the tonsillar carrier state of S. suis. Six antimicrobial regimens were tested: penicillin intramuscularly (IM) once daily (s.i.d.) for 3 consecutive days; penicillin IM s.i.d. for 5 consecutive days; ampicillin IM s.i.d. for 5 consecutive days; ampicillin per os s.i.d. for 5 consecutive days; ampicillin intranasally s.i.d. for 5 consecutive days; and ceftiofur sodium IM s.i.d. for 5 consecutive days. The seventh group consisted of untreated control pigs. Tonsillar swab samples were collected before treatment, and tonsillar tissue samples were collected after treatment for cultural examination for S. suis. Streptococcus suis was identified in pigs from all groups prior to treatment and after treatment. Pigs did not have clinical signs of disease during the study. All antimicrobial treatments tested in this study failed to eliminate the tonsillar carrier state of S. suis. Early weaning and medication used in this study were not effective for the elimination of the tonsillar carrier state of S. suis in pigs. Optimization of management and environment of pigs coupled with strategic medication of clinically ill animals should be used for control and prevention of mortality caused by streptococcosis.
从感染猪链球菌的猪群中选取10窝共70头临床健康的13日龄杂交仔猪，按窝别和体重随机分为7组，每组10头，以确定不同的抗生素治疗方案是否能消除猪链球菌的扁桃体携带状态。测试了六种抗菌方案：青霉素每日一次肌肉注射（IM），连续3天；青霉素每日一次肌肉注射，连续5天；氨苄西林每日一次肌肉注射，连续5天；氨苄西林每日一次口服，连续5天；氨苄西林每日一次滴鼻，连续5天；头孢噻呋钠每日一次肌肉注射，连续5天。第七组为未治疗的对照仔猪。治疗前采集扁桃体拭子样本，治疗后采集扁桃体组织样本进行猪链球菌培养检查。治疗前后所有组的猪均检测到猪链球菌。研究期间猪没有疾病的临床症状。本研究中测试的所有抗菌治疗均未能消除猪链球菌的扁桃体携带状态。本研究中使用的早期断奶和药物治疗对消除猪扁桃体携带猪链球菌状态无效。应优化猪的管理和环境，并对临床患病动物进行策略性用药，以控制和预防由链球菌病引起的死亡。
