Day D N, Sparks J W, Karriker L A, Stalder K J, Wulf L W, Zhang J, Kinyon J M, Stock M L, Gehring R, Wang C, Ellingson J, Coetzee J F
Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Department of Animal Science, Iowa State University, Ames, IA, USA.
J Vet Pharmacol Ther. 2015 Oct;38(5):475-81. doi: 10.1111/jvp.12209. Epub 2015 Feb 16.
This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR-2385 (10(5.75) 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX , but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs.
本研究确定了猪生殖与呼吸综合征病毒（PRRSV）和猪链球菌混合感染对盐酸头孢噻呋在猪肌肉注射后药代动力学（PK）特征的影响。将18头临床正常的杂交后备母猪按体重分为攻毒组（10头猪）和对照组（8头猪）。两组猪均以5mg/kg体重的剂量肌肉注射一次盐酸头孢噻呋（Excenel RTU无菌混悬液；硕腾公司）。采集系列血样以描绘血浆浓度曲线。经过10天的药物洗脱期后，攻毒组经鼻接种2mL PRRSV分离株VR - 2385（每毫升含10(5.75) 50%组织培养感染剂量），8天后接种猪链球菌。当出现明显临床疾病时，在攻毒组和对照组同时开始第二次PK评估。混合感染的猪表现出较低的AUC和CMAX值，但Cl/F和Vz/F值较高，表明感染改变了药物动力学。本研究的数据对患病猪的头孢噻呋治疗方案具有启示意义。
