[The biological range and characteristics of the importance of adenosine receptors for the resistance of the brain to total ischemia].

In the total brain ischemia the cerebroprotective effect (CPE) of adenosine was pronounced in the following order: mouse > rat approximately guinea pig (males > females). The sensitizing effect (SE) of theophylline is the same in different species but is more pronounced in females compared to males. Newborn rats are much more tolerant to the total brain ischemia. The adenosine CPE increases and the theophylline SE decreases with age. The adenosine receptor component, evidently, contributes greatly to the natural tolerance of newborn animals to the total brain ischemia.