Fenice O, Austoni E, Giudice V
Facoltà di Medicina e Chirurgia, Cattedra di Urologia, Università degli Studi di Milano.
Arch Ital Urol Androl. 1996 Dec;68(5):379-88.
Microscopic procedures for therapy of obstructive azoospermia or of vasectomy reversals have resulted in accurate reapproximation of ductal structures. The success of vasovasostomy appears to be influenced by the length of time that has passed since the vasectomy was performed or the obstruction become. Failures of vasovasostomy may be attributed to anastomotic stenosis, sperm antibodies, epididymal dysfunction, or an unrecognized epididymal tubule blowout with subsequent obstruction. The latter condition should by suspected when, at the time of the initial vasovasostomy, there is lack of fluid containing spermatozoa in the cut end of the testicular portion of the vas. Chronic intratubular pressure may cause an epididymal blowout, with subsequent spermatic granuloma and obstruction in the epididymal tubule, that may also be related to a congenital disorder or a postinflammatory condition. Spermatozoa gain maturation and the capacity for motility as they move from the caput to the cauda of the epididymis as possible. Microsurgery allows direct microtubular anastomosis between the epididymal tubule and the cut end of the vas. Some conditions are not amenable to conventional surgical techniques, such obstructed azoospermia due to congenital bilateral absence of the vas deferens or to severe damage to the reproductive ducts. To treat these patients surgeons have devised reservoirs (artificial spermatoceles) to collect spermatozoa to be used for artificial insemination. An alternative treatment method for obstructed azoospermia is to obtain sperm from the epididymis with the use of an operating microscope. Although sperm have been obtained the poor sperm motility requires either in vitro fertilization or GIFT. The technique looks promising, although improved techniques to enhance the motility of the collected sperm will ultimately yield better results.
治疗梗阻性无精子症或输精管复通的显微手术已实现导管结构的精确重新吻合。输精管吻合术的成功率似乎受输精管结扎术施行后或梗阻形成后所经历时间长短的影响。输精管吻合术失败可能归因于吻合口狭窄、精子抗体、附睾功能障碍,或未被识别的附睾小管破裂并随后发生梗阻。当初次输精管吻合术时,如果输精管睾丸段断端缺乏含精子的液体,就应怀疑存在后一种情况。慢性管腔内压力可能导致附睾破裂,随后形成精子肉芽肿和附睾小管梗阻,这也可能与先天性疾病或炎症后状况有关。精子在从附睾头向附睾尾移动的过程中逐渐成熟并获得运动能力。显微外科手术可实现附睾小管与输精管断端之间的直接微管吻合。有些情况不适用于传统手术技术,如先天性双侧输精管缺如或生殖管道严重受损导致的梗阻性无精子症。为治疗这些患者,外科医生设计了储器(人工精液囊肿)来收集用于人工授精的精子。梗阻性无精子症的另一种治疗方法是在手术显微镜下从附睾获取精子。尽管已获取精子,但精子活力差需要进行体外受精或配子输卵管内移植。该技术看起来很有前景,不过,提高所收集精子活力的改进技术最终将产生更好的效果。