Veerkamp J H, Van Moerkerk H T, Van den Born J
Department of Biochemistry, University of Nijmegen, The Netherlands.
Int J Biochem Cell Biol. 1996 Apr;28(4):473-8. doi: 10.1016/1357-2725(95)00150-6.
Fatty acid-binding protein is considered to play an important role in fatty acid oxidation. Since diabetes mellitus causes marked changes of this latter metabolic process, we compared the effect of this pathological condition on both parameters in a comparative investigation of different rat tissues. Palmitate oxidation capacity and content of fatty acid-binding protein were determined in liver, heart and quadriceps muscle from rats with 2-week streptozotocin-induced diabetes mellitus and controls. In liver homogenates fatty acid oxidation capacity increased by 90%, but their content of fatty acid-binding protein decreased by 35%. Fatty acid oxidation capacity of heart and quadriceps muscle and fatty acid-binding protein content of quadriceps muscle did not change, but fatty acid-binding protein content of heart muscle doubled. Long-term diabetes (8 months) had a similar effect on content of this protein. In summary, changes of fatty acid oxidation capacity do not appear to correlate with fatty acid-binding protein content during the development of diabetes. This does not preclude other functions of fatty acid-binding proteins in regulation of lipid metabolism and processes in which fatty acids play a modulatory role.
脂肪酸结合蛋白被认为在脂肪酸氧化过程中发挥重要作用。由于糖尿病会导致这一后期代谢过程发生显著变化，我们在一项针对不同大鼠组织的比较研究中，比较了这种病理状况对这两个参数的影响。测定了链脲佐菌素诱导糖尿病2周的大鼠及对照组大鼠肝脏、心脏和股四头肌中的棕榈酸氧化能力和脂肪酸结合蛋白含量。在肝脏匀浆中，脂肪酸氧化能力增加了90%，但其脂肪酸结合蛋白含量下降了35%。心脏和股四头肌的脂肪酸氧化能力以及股四头肌的脂肪酸结合蛋白含量没有变化，但心肌中的脂肪酸结合蛋白含量增加了一倍。长期糖尿病（8个月）对该蛋白含量有类似影响。总之，在糖尿病发展过程中，脂肪酸氧化能力的变化似乎与脂肪酸结合蛋白含量无关。这并不排除脂肪酸结合蛋白在脂质代谢调节以及脂肪酸起调节作用的过程中的其他功能。
