[淋巴细胞抑素对抗氧化物质缺乏时淋巴细胞功能活性的影响及其维生素E纠正作用]
[The effect of lymphocytic chalone on lymphocyte functional activity in antioxidant deficiency and its correction with vitamin E].
作者信息
Harkava K H, Afonina H B, Zadorina O V, Briuzhina T S
出版信息
Fiziol Zh (1994). 1995 Sep-Dec;41(5-6):27-32.
Activity of lymphocyte chalone-tissue-specific inhibitor of cell proliferation and its effect on immunocompetent cells in antioxidant insufficiency (AOI) and its correction with vitamin E were studied in the work. It was stated that lymphocyte chalone quantity in AOI increased 2 times as compared with control values and was at the same level when using alpha-tocopherol acetate. The inhibiting activity of chalone was preserved in relation to the proliferative activity of lymphocytes and disappeared in relation to DNA-synthesis with immunocompetent cells. The study of fatty acids spectrum of lymphocyte membrane phospholipids has shown that lymphocyte chalone normalized the content of saturated and unsaturated fatty acids that demonstrates the antioxidant properties of lymphocyte chalone.
本研究探讨了淋巴细胞抑素（细胞增殖的组织特异性抑制剂）的活性及其在抗氧化不足（AOI）状态下对免疫活性细胞的影响，以及维生素E对其的纠正作用。结果表明，与对照值相比，AOI状态下淋巴细胞抑素的量增加了2倍，而使用醋酸α-生育酚时其处于相同水平。抑素对淋巴细胞增殖活性的抑制作用得以保留，但对免疫活性细胞DNA合成的抑制作用消失。淋巴细胞膜磷脂脂肪酸谱的研究表明，淋巴细胞抑素使饱和脂肪酸和不饱和脂肪酸的含量正常化，这证明了淋巴细胞抑素的抗氧化特性。
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