Cailleux N, Levesque H, Courtois H, Borg J Y
Département de Médecine Interne, Hôpital de Boisguillaume, CHU de Rouen.
J Mal Vasc. 1996;21(5):324-8.
The finding of a prolonged partial thromboplastin time and a normal prothrombin time localized the coagulation defect to the intrinsic or contact activation limb of the coagulation cascade. Because the situation is a source of hemorrhage, a rational and rapid approach is necessary with measure of factors of intrinsic limb of coagulation (especially factors VIII and IX, for the diagnosis of classic hemophilia), study of von Willebrand factor and search of coagulation factor inhibitors. We report the case of a 25-year old woman with high titer postpartum antibody against factor VIII for illustrating the diagnosis approach.
活化部分凝血活酶时间延长而凝血酶原时间正常，这一检查结果提示凝血缺陷定位于凝血级联反应的内源性或接触激活途径。由于这种情况是出血的一个原因，因此需要采取合理且快速的方法，检测内源性凝血途径的相关因子（特别是因子VIII和IX，用于诊断典型血友病），研究血管性血友病因子并查找凝血因子抑制剂。我们报告了一例25岁产后女性的病例，其体内存在高滴度的抗因子VIII抗体，以此来说明诊断方法。
