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黏膜上皮细胞与微生物——细胞内寄生虫的相互关系

[The interrelations of mucosal epithelial cells with microbes--intracellular parasites].

作者信息

Domaradskiĭ I V, Babin V N

出版信息

Med Parazitol (Mosk). 1996 Oct-Dec(4):3-8.

PMID:9026669
Abstract

On the basis of information at hand, it can be concluded that there are principal limits on the capture of bacteria by epithelial cells in the gastrointestinal tract and other cavities. Although entry is, however, a result both of bacteria and epithelial cells, it is frequently induced by parasite-directed endocytosis and may also accompanied by passive entry of nonpathogenic bacteria. The induction of parasite-induced endocytosis should be regarded as a consequence of a fundamental concept in biology, namely: molecular and cellular recognition wherein bacterial adhesion to the host's cell receptors is of great importance. In this connection, discussion covers the origin of corresponding receptors. The authors share the opinion in that epithelial cells, those of the gastrointestinal tract in particular, are part of the human common mucosal immune system.

摘要

根据现有信息,可以得出结论:胃肠道和其他腔道中的上皮细胞捕获细菌存在主要限制。然而,尽管细菌进入上皮细胞是细菌和上皮细胞共同作用的结果,但它通常是由寄生虫介导的内吞作用诱导的,也可能伴随着非致病性细菌的被动进入。寄生虫诱导的内吞作用的诱导应被视为生物学中一个基本概念的结果,即:分子和细胞识别,其中细菌与宿主细胞受体的粘附非常重要。在此方面,讨论涵盖了相应受体的起源。作者们一致认为,上皮细胞,尤其是胃肠道的上皮细胞,是人类共同黏膜免疫系统的一部分。

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