Signorelli P, Croce P, Dedè A
Divisione di Ostetricia e Ginecologia, Ospedale di Codogno, Regione Lombardia, USL n. 25, Lodi.
Minerva Ginecol. 1996 Dec;48(12):577-82.
Constipation is a problem frequently encountered during pregnancy as is excessive weight gain. Treatments of common use to control constipation are endowed with some drawbacks and they are not active in controlling weight increase. A preparation of lactulose and glucomannan in previous studies proved very effective and well tolerated in patients affected by stypsis and evidentiated also activity both in controlling excessive food intake and in correcting some metabolic imbalances regarding lipids and urea.
50 pregnant females affected by constipation were treated with sachets containing a preparation of glucomannan (1.45 g) and lactulose (4.2 g) in a posology of 2 (1-4) sachets a day for 1-3 months.
Treatment induced a return to normal frequency of weekly number of evacuations (4.9-5.8/week) and a parallel control of weight gain (within 20% of initial body weight). The latter finding seems to be related to hunger control induced by glucomannan at the gastric level which prevents an excessive food intake.
便秘是孕期常见问题，体重过度增加也是如此。常用的控制便秘的治疗方法存在一些缺点，且对控制体重增加无效。先前研究中一种乳果糖和葡甘露聚糖制剂在脓毒症患者中证明非常有效且耐受性良好，还显示出在控制过量食物摄入以及纠正一些脂质和尿素代谢失衡方面的活性。
50名便秘的怀孕女性接受含有葡甘露聚糖（1.45克）和乳果糖（4.2克）制剂的药包治疗，剂量为每天2（1 - 4）包，持续1 - 3个月。
治疗使每周排便次数恢复正常（4.9 - 5.8次/周），并同时控制了体重增加（在初始体重的20%以内）。后一发现似乎与葡甘露聚糖在胃部水平引起的饥饿控制有关，从而防止了过量食物摄入。
