Zhou Yu, Yang Xinghua, Fan Ling, Zhu Yuanfang, Jiang Yurong, Li Zhen, Xiong Guoping, Shen Jingxin, Su Zhihong, Wu Ping, Wang Danrui, Wang Xietong
Department of Obstetrics, Shandong Province Hospital Jinan 250014, Shandong, China.
School of Public Health, Capital Medical University Beijing 100069, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):19167-71. eCollection 2015.
To evaluate the efficacy and safety of lactulose in the intervention treatment of postpartum women with constipation.
The study adopted the multicenter clinical survey with a big sample which enrolled 4781 valid questionnaires from postpartum women in 18 different districts. All of them were treated with lactulose oral solution. Their constipation-related symptoms and routine examination on blood, urine and stool were monitored before and after lactulose intervention. The treatment duration lasted 2 weeks and all the patients were followed for 4 weeks.
Their stool consistency, daily defecation frequencies, defecating time and dyschezia were improved significantly after lactulose intervention, and the good therapeutic effect was remained at the off-medication session. Furthermore, abnormal rate of each index in blood, urine and stool examination showed a decreased trend.
Lactulose offered good therapeutic benefit and could be developed as an effective intervention to postpartum women with constipation.
评估乳果糖对产后便秘妇女进行干预治疗的疗效和安全性。
本研究采用多中心大样本临床调查，收集了来自18个不同地区产后妇女的4781份有效问卷。所有受试者均接受乳果糖口服液治疗。在乳果糖干预前后监测其便秘相关症状以及血液、尿液和粪便常规检查。治疗持续2周，所有患者随访4周。
乳果糖干预后，她们的大便性状、每日排便次数、排便时间和排便困难均有显著改善，且停药期仍保持良好治疗效果。此外，血液、尿液和粪便检查各指标异常率呈下降趋势。
乳果糖具有良好的治疗效果，可开发成为产后便秘妇女的有效干预措施。
