Jaim-Etcheverry G, Zieher L M
Eur J Pharmacol. 1977 Sep 15;45(2):105-16. doi: 10.1016/0014-2999(77)90080-2.
6-Hydroxydopamine or 6-hydroxydopa injected systemically into newborn rats produced marked changes in the development of central and peripheral noradrenergic neurons. Noradrenaline concentration was elevated in the brain stem, particularly in the pons, and decreased in the cerebral cortex and the spinal cord while in the cerebellum, the effects were dependent on the mode of administration. The changes produced by 6-hydroxydopa in brain regional noradrenaline were related to the dose injected at birth. Similar modifications in the development of central noradrenergic neurons were found in the offspring of rats which had received 6-hydroxydopa at 16 days of gestation. The involvement of peripheral sympathetic neurons varied with the compound used and the form of its administration. Thus, 6-hydroxydopamine produced a permanent although partial peripheral sympathectomy, an effect which was less evident following multiple injections of 6-hydroxydopa after birth and almost minimal after a single injection. The prenatal administration of 6-hydroxydopa did not alter peripheral sympathetic neurons. It is concluded that with the appropriate treatment schedule, it is possible to lesion selectively the noradrenergic neurons in the central nervous system.
将6-羟基多巴胺或6-羟基多巴全身注射到新生大鼠体内，会使中枢和外周去甲肾上腺素能神经元的发育产生显著变化。脑干中的去甲肾上腺素浓度升高，尤其是在脑桥，而大脑皮层和脊髓中的浓度降低，而在小脑中，其影响取决于给药方式。6-羟基多巴对脑区去甲肾上腺素产生的变化与出生时注射的剂量有关。在妊娠16天时接受过6-羟基多巴的大鼠后代中，也发现了中枢去甲肾上腺素能神经元发育的类似改变。外周交感神经元的受累情况因所用化合物及其给药形式而异。因此，6-羟基多巴胺会导致永久性但部分性的外周交感神经切除术，出生后多次注射6-羟基多巴后这种效应不太明显，单次注射后几乎微乎其微。产前给予6-羟基多巴不会改变外周交感神经元。得出的结论是，通过适当的治疗方案，有可能选择性地损伤中枢神经系统中的去甲肾上腺素能神经元。
