Iakhno N N, Damulin I V, Zakharov V V, Levin O S, Elkin M N
Ter Arkh. 1996;68(10):65-9.
The efficacy and tolerability of high-dose neurotrophic drug cerebrolysin was studied in 20 patients with vascular dementia diagnosed by criteria NINDS-AIREN and DSM-IV. The drug was well tolerated, affected positively cognitive function, especially neurodynamic processes. EEG featured after treatment intensification of rapid rhythms power and a decrease in delta-activity spectrum. The highest effect of cerebrolysin was achieved in patients with mild cognitive defects.
采用NINDS-AIREN和DSM-IV标准，对20例血管性痴呆患者进行了大剂量神经营养药物脑蛋白水解物的疗效和耐受性研究。该药物耐受性良好，对认知功能有积极影响，尤其是对神经动力学过程。治疗后脑电图特征为快节律功率增强，δ活动谱降低。脑蛋白水解物对轻度认知缺陷患者效果最佳。
