[The age-dependent incidence of Down's syndrome and the free-radical theory].

Age-dependent distribution of Down syndrome frequency in the light of free-radical theory of aging was carried out in this work. The frequency of Down syndrome had been analysed during the period of 1990-1995. The investigation of radical process intensity was performed in the group of women of child-bearing age by the chemoluminescence method. It has been demonstrated that the age of a woman is one of the main reasons both of Down syndrome frequency increase and free radical accumulation. The obtained analogy between age-dependent distribution of Down syndrome frequency and age-dependent accumulation of free radicals is one more argument for the role of free radicals in the pathogenesis of Down syndrome.