[列宁格勒地区唐氏综合征患儿出生发病率及风险的增加（1982 - 1989年）]

[Increase in the incidence and risk of birth of children with Down's syndrome in Leningrad (1982-1989)].

作者信息

Kovaleva N V, Butomo I V, Verlinskaia D K, Il'iashenko T N, Davidenkova E F

出版信息

Genetika. 1994 Feb;30(2):265-70.

Abstract

Among 559,286 infants born in Leningrad in 1982-1989, there was revealed 744 infants (1.33/1000) with Down's syndrome (DS). The age distribution for their mothers as well as for 79,571 parturient women in the general population was investigated. The data regarding the period studied was compared with the results of a similar investigation conducted during of 1945-1961. A decrease in maternal age in the population was demonstrated. This was more pronounced for the mothers of affected infants. A 1.4- to 2.2-fold increase of birth risks for DS was found in all maternal age groups. The doubling of the risk value occurred by the age of 30-34, in contrast to 35-39 in 1945-1961.

摘要

在1982年至1989年于列宁格勒出生的559,286名婴儿中，发现了744名患有唐氏综合征（DS）的婴儿（发病率为1.33/1000）。对这些患病婴儿母亲的年龄分布以及一般人群中79,571名产妇的年龄分布进行了调查。将研究期间的数据与1945年至1961年期间进行的类似调查结果进行了比较。结果表明，总体人群中产妇年龄有所下降，这在患病婴儿的母亲中更为明显。在所有产妇年龄组中，唐氏综合征的出生风险增加了1.4至2.2倍。风险值翻倍发生在30至34岁，而在1945年至1961年则是35至39岁。