Pleskach N M, Mikhel'son V M, Raams A, Bootsma D
Tsitologiia. 1996;38(8):863-8.
Complementation groups for xeroderma pigmentosum (XP) and Cockayne's syndrome (CS) cells have been first determined for patients encountered in the former Soviet Union. The determination was carried out using fusion of fibroblasts to be examined with those of already known complementation groups, and subsequently registering the level of DNA unscheduled synthesis (for XP cells) and RNA synthesis recovery (for CS cells) after UV-irradiation. The evidence of the complementation was normalization of these indexes. Cells of XP2SP and XP4SP patients are shown to fall under the XPC complementation group, whereas CS1SP cells are classified within the CSA complementation group.
针对在前苏联遇到的患者,首次确定了着色性干皮病(XP)和科凯恩综合征(CS)细胞的互补组。确定过程是将待检测的成纤维细胞与已知互补组的成纤维细胞融合,随后记录紫外线照射后DNA非预定合成水平(针对XP细胞)和RNA合成恢复情况(针对CS细胞)。互补的证据是这些指标的正常化。结果显示,XP2SP和XP4SP患者的细胞属于XPC互补组,而CS1SP细胞则归类于CSA互补组。