Hodgson G, Blackett N
Exp Hematol. 1977 Sep;5(5):423-6.
Four injections of hydroxyurea 1 mg/g body weight, given to normal mice 31, 24, 10 and 7 h before sampling bone marrow, reduced CFU-S content of femoral marrow to 30% of normal in Balb/c female and to 10% of normal in C57 B1 male mice. Over 80% of the surviving CFU-S were in the S phase of cycle, as judged from their sensitivity to killing by hydroxyurea or ARA-C.
在对正常小鼠采集骨髓前31、24、10和7小时，给予其4次1毫克/克体重的羟基脲注射，结果Balb/c雌性小鼠股骨骨髓中的脾集落形成单位（CFU-S）含量降至正常水平的30%，C57 B1雄性小鼠降至正常水平的10%。根据其对羟基脲或阿糖胞苷杀伤的敏感性判断，超过80%存活的CFU-S处于细胞周期的S期。
