Granov A M, Tarazov P G, Polikarpov A A
Vestn Rentgenol Radiol. 1996 Nov-Dec(6):23-6.
The treatment outcomes were analysed in 37 patients with intrahepatic arterioportal fistulas (IAPF) of various etiology. In 21 patients with fistulas in the presence of hepatoma, surgical resection (n = 4), hepatic arterial embolization with a hemostatic sponge and metallic spirals (n = 7) and conservative therapy (n = 10) were used. In 4 large iatrogenic IAPF, embolization was conducted just after making a diagnosis; in other 7 cases, a follow-up was accompanied by control arteriography. Embolization was done in all 5 patients with large spontaneous IAPF in the intact and cirrhosis- or hemangioma-related liver. One fatal outcome was observed after embolization in the presence of severe hepatic failure. No other complications were registered. Symptoms of elevated pressures in the portal vein regressed in most patients. It is concluded that despite the cause of occurrence, long-term IAPF results in hyperkinetic portal hypertension, followed by bleeding from the esophageal and gastric varicosity. Arterial embolization of IAPF in the hepatoma reduces the risk for fatal hemorrhage. Small iatrogenic IAPF should be followed up by making control arteriography. Arterial occlusion is the treatment of choice for spontaneous and persistent iatrogenic IAPF. Severe chronic hepatic failure is a contraindication for embolization.
对37例不同病因的肝内动脉门静脉瘘(IAPF)患者的治疗结果进行了分析。21例合并肝癌的瘘患者,采用了手术切除(n = 4)、用止血海绵和金属螺旋圈进行肝动脉栓塞(n = 7)以及保守治疗(n = 10)。4例大型医源性IAPF患者在确诊后立即进行了栓塞;其他7例患者在随访时进行了对照动脉造影。5例完整肝脏、肝硬化或血管瘤相关肝脏的大型自发性IAPF患者均进行了栓塞。1例在严重肝功能衰竭情况下栓塞后出现致命结局。未记录到其他并发症。大多数患者门静脉压力升高的症状有所缓解。结论是,无论病因如何,长期IAPF都会导致高动力性门静脉高压,继而引发食管和胃静脉曲张出血。肝癌患者IAPF的动脉栓塞可降低致命性出血的风险。小型医源性IAPF应通过对照动脉造影进行随访。动脉闭塞是自发性和持续性医源性IAPF的首选治疗方法。严重慢性肝功能衰竭是栓塞的禁忌证。