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[AO交锁髓内钉治疗下肢骨转移瘤的外科治疗]

[Surgical management of bone metastases of the lower extremity with AO interlocking nail].

作者信息

Krawzak H W, Heistermann H P, Ibing H P, Meffert R, Hohlbach G

机构信息

Chirurgische Universitätsklinik, Ruhr-Universität Bochum, Marienhospital, Herne.

出版信息

Zentralbl Chir. 1996;121(11):994-8; discussion 999.

PMID:9027156
Abstract

Between January 1991 and June 1995 we have operated on 19 patients (9 male, 10 female) with 22 skeletal metastases of the lower limb (19 femora, 3 tibiae) using a static interlocking nail. Closed intramedullary nailing without resection of the metastasis has been established as our standard procedure. We have stabilized 15 patients with advanced osteolysis and seven pathological fractures. Sixteen patients underwent postoperative local radiation therapy with 40 Gy. As intraoperative complications we have observed one fracture of an osteolysis and one death due to fat embolism. Postoperatively there were observed one seroma, one haematoma and one patient with non fatal pulmonary embolism following DVT. Two patients died within the first 30 postoperative days because of tumor progression. All patients surviving longer than 30 days could be mobilized under full weight-bearing. Morphine like analgetics for metastasis related pain were no longer needed. A secondary instability has not been observed within a mean survival time of 199 days (811 longest follow up). Closed intramedullary nailing in combination with postoperative local radiation therapy seems to be an appropriate and technically non demanding procedure to stabilize skeletal metastases of the lower limb in patients with a short or medium-term expectation of life.

摘要

1991年1月至1995年6月期间,我们使用静力交锁髓内钉对19例(9例男性,10例女性)下肢22处骨骼转移瘤(19处股骨,3处胫骨)患者进行了手术。不切除转移瘤的闭合髓内钉固定术已成为我们的标准手术方法。我们使15例晚期骨质溶解和7例病理性骨折患者获得了稳定。16例患者术后接受了40 Gy的局部放疗。术中并发症方面,我们观察到1例骨质溶解骨折和1例因脂肪栓塞死亡的病例。术后观察到1例血清肿、1例血肿以及1例深静脉血栓形成后发生非致命性肺栓塞的患者。2例患者术后30天内死于肿瘤进展。所有存活超过30天的患者均可在完全负重情况下活动。不再需要使用吗啡类镇痛药来缓解转移相关疼痛。在平均199天的生存时间(最长随访811天)内未观察到继发性不稳定情况。对于预期寿命较短或中期的患者,闭合髓内钉固定术联合术后局部放疗似乎是稳定下肢骨骼转移瘤的一种合适且技术要求不高的手术方法。

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