昼夜节律与自动调节转录环——循环往复？

Circadian rhythms and autoregulatory transcription loops--going round in circles?

作者信息

Carter D A, Murphy D

机构信息

Physiology Unit, School of Molecular and Medical Biosciences, Cardiff University of Wales, UK.

出版信息

Mol Cell Endocrinol. 1996 Nov 29;124(1-2):1-5. doi: 10.1016/s0303-7207(96)03962-7.

DOI:10.1016/s0303-7207(96)03962-7

PMID:9027318

Abstract

Recent advances in the molecular analysis of biological timing have appeared to bring us closer to an answer to the 'big question', namely, 'What is the timing mechanism that enables an organism to measure the circadian (around 24 h) period?'. In this minireview, we consider the validity of the fashionable concept that autoregulatory feedback loops, centered on transcription, form the basis of the clock, and we offer a fresh view of recent progress as it relates to mammalian systems.

摘要

生物节律分子分析的最新进展似乎使我们更接近于回答“重大问题”，即“使生物体能够测量昼夜节律（约24小时）周期的计时机制是什么？”。在这篇小型综述中，我们探讨了以转录为中心的自动调节反馈环构成生物钟基础这一流行概念的合理性，并就与哺乳动物系统相关的最新进展提出了新观点。