Chang A C, Dunham M A, Jeffrey K J, Reddel R R
Children's Medical Research Institute, Westmead, Sydney NSW, Australia.
Mol Cell Endocrinol. 1996 Nov 29;124(1-2):185-7. doi: 10.1016/s0303-7207(96)03929-9.
In bony fish, stanniocalcin is a glycoprotein hormone thought to be an important regulator of calcium uptake from the aquatic environment. Although stanniocalcin was previously thought to be unique to fish, recent evidence has indicated the existence of a human homologue. To facilitate studies of the function of stanniocalcin in mammals, we have now isolated the mouse stanniocalcin cDNA. This cDNA encodes a predicted protein of the same length as its human counterpart and with a high level of similarity (238/247) amino acids are identical, and five represent conservative changes). As in human, the mRNA is expressed in many mouse tissues, suggesting that mammalian stanniocalcin has a paracrine rather than endocrine role.
在硬骨鱼中，鲽鱼降钙素是一种糖蛋白激素，被认为是从水生环境中摄取钙的重要调节因子。尽管鲽鱼降钙素以前被认为是鱼类所特有的，但最近的证据表明存在人类同源物。为了便于研究鲽鱼降钙素在哺乳动物中的功能，我们现在分离出了小鼠鲽鱼降钙素cDNA。该cDNA编码的预测蛋白长度与其人类对应物相同，且具有高度相似性（247个氨基酸中有238个相同，5个为保守变化）。与人类一样，该mRNA在许多小鼠组织中表达，这表明哺乳动物鲽鱼降钙素具有旁分泌而非内分泌作用。
