Siniukhin V N, Pochatov Iu M, Rodionov A P
Farmakol Toksikol. 1977 Jul-Aug;40(4):464-8.
Thin-layer and gas chromatography, spectrophotometry and mass-spectrometry were employed in studying metabolism of the neuroleptic azabutyron in man. It was ascertained that azabutyron is eliminated from the human organism in 24 hours unchanged (10 per cent of the dose administered). The main ways of its metabolism are oxidative N-dealkylation, reduction of the carboxylic group in the molecule, N-oxidation and conjugation of the drug.
采用薄层色谱法、气相色谱法、分光光度法和质谱分析法研究了抗精神病药物阿扎丁在人体中的代谢情况。已确定阿扎丁在24小时内以原形从人体排出（占给药剂量的10%）。其主要代谢途径为氧化N-去烷基化、分子中羧基还原、N-氧化以及药物的结合反应。
