Haddad G G
Department of Pediatrics (Section of Respiratory Medicine), Yale University School of Medicine, New Haven, Connecticut, USA.
Kidney Int. 1997 Feb;51(2):467-72. doi: 10.1038/ki.1997.63.
This is an exciting area of research for at least two reasons: (1) it has high clinical visibility and potential implications that transcend age, tissue, and cell type. (2) Currently there are very powerful armamentaria to solve questions and we are starting to apply this in this area of research. Hence, the possibility for understanding how hypoxia induces injury or why do cells survive anoxia is within reach. I hope that within the foreseeable future we will be able to solve some of these questions at the molecular level and start to target some of the important pathways for pharmacologic and drug interventions.
这是一个令人兴奋的研究领域，至少有两个原因：（1）它具有很高的临床关注度，其潜在影响超越了年龄、组织和细胞类型。（2）目前有非常强大的研究手段来解决问题，我们也开始将其应用于这个研究领域。因此，理解缺氧如何导致损伤或细胞为何能在缺氧状态下存活的可能性已触手可及。我希望在可预见的未来，我们能够在分子水平上解决其中一些问题，并开始针对一些重要途径进行药理和药物干预。
