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C型凝集素相关蛋白是由金属蛋白酶/解整合素前体蛋白经蛋白水解作用产生的吗？

Are C-type lectin-related proteins derived by proteolysis of metalloproteinase/disintegrin precursor proteins?

作者信息

Kini R M

机构信息

Bioscience Centre, Faculty of Science, National University of Singapore.

出版信息

Toxicon. 1996 Nov-Dec;34(11-12):1287-94. doi: 10.1016/s0041-0101(96)00107-9.

DOI:10.1016/s0041-0101(96)00107-9
PMID:9027984
Abstract

Metalloproteinases and disintegrins, non-enzymatic inhibitors of platelet aggregation, are derived by proteolysis from common precursors. A closer examination of the cDNA and amino acid sequences of these precursors indicated that the putative signal peptide may be an internal hydrophobic segment and that the sequences are incomplete at the 5'-region. The studies indicated that C-type lectin-related proteins are also derived from the amino terminal region of these precursors. Based on these findings, a five-domain structure is proposed for the precursors.

摘要

金属蛋白酶和去整合素是血小板聚集的非酶抑制剂，由共同前体经蛋白水解产生。对这些前体的cDNA和氨基酸序列进行更深入的研究表明，推定的信号肽可能是一个内部疏水片段，并且这些序列在5'-区域不完整。研究表明，C型凝集素相关蛋白也源自这些前体的氨基末端区域。基于这些发现，提出了前体的五结构域结构。

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