Hashimoto S, Hiyoshi M, Hino M, Yamane T, Ota T, Koh K R, Tagawa S, Tatsumi N
Department of Clinical Hematology, Osaka City University Medical School.
Rinsho Ketsueki. 1997 Jan;38(1):72-4.
Chronic myelogenous leukemia (CML) expresses two types of bcr-abl chimeric mRNA. One is b3a2 type in which bcr exon 3 binds to abl exon 2, the other is b2a2 type that bcr exon 2 binds to abl exon 2. Either bcr-abl is normally expressed, but both types of bcr-abl mRNA can be expressed at the same time in a patient. We report here a rare case of CML expressing two types of bcr-abl mRNA and discuss the possibility that this double expression would help to monitor the clinical course of CML.
