甲状腺癌的预后因素。一项基于人群的研究，涉及1973 - 1991年监测、流行病学和最终结果（SEER）项目中的15698例病例。

Prognostic factors for thyroid carcinoma. A population-based study of 15,698 cases from the Surveillance, Epidemiology and End Results (SEER) program 1973-1991.

作者信息

Gilliland F D, Hunt W C, Morris D M, Key C R

机构信息

Department of Medicine, University of New Mexico Medical Center, Albuquerque, 87131-5306, USA.

出版信息

Cancer. 1997 Feb 1;79(3):564-73. doi: 10.1002/(sici)1097-0142(19970201)79:3<564::aid-cncr20>3.0.co;2-0.

DOI:10.1002/(sici)1097-0142(19970201)79:3<564::aid-cncr20>3.0.co;2-0

PMID:9028369

Abstract

BACKGROUND

A number of prognostic factors for thyroid carcinoma have been identified, including sociodemographic characteristics, such as age and gender, and tumor characteristics, such as histology and stage. The relative importance of these factors as independent predictors of survival for patients with papillary, follicular, anaplastic, and medullary thyroid carcinoma has been extensively studied but remains uncertain.

METHODS

The authors used data collected by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute between 1973 and 1991 to investigate prognostic factors for each of the major histologic types of thyroid carcinoma in a population-based patient series and to assess the effect of these factors as predictors of survival.

RESULTS

Both tumor and sociodemographic characteristics were independently associated with survival. Patients with papillary carcinoma had the highest 10-year relative survival (0.98), followed by those with follicular carcinoma (0.92) and medullary carcinoma (0.80). Anaplastic tumors had the lowest 10-year relative survival (0.13). Stage at diagnosis and differentiation status were strong independent prognostic factors for each histologic type. Advanced stage at diagnosis was a stronger prognostic factor for medullary carcinoma than for other histologic types. Increasing age was associated with lower relative survival for each histologic type. Gender, marital status, and ethnicity were significant, but weaker, predictors of survival.

CONCLUSIONS

Survival varied markedly among patients with different histologic types of thyroid carcinoma. Stage at diagnosis and tumor differentiation were important prognostic factors for each histologic type. Age at diagnosis was a stronger predictor of survival for patients with follicular and medullary carcinoma than for patients with papillary carcinoma.

摘要

背景

已确定了一些甲状腺癌的预后因素，包括社会人口学特征，如年龄和性别，以及肿瘤特征，如组织学类型和分期。这些因素作为乳头状、滤泡状、未分化和髓样甲状腺癌患者生存的独立预测因素的相对重要性已得到广泛研究，但仍不确定。

方法

作者使用了美国国立癌症研究所监测、流行病学和最终结果（SEER）计划在1973年至1991年期间收集的数据，以调查基于人群的患者系列中每种主要组织学类型甲状腺癌的预后因素，并评估这些因素作为生存预测因素的作用。

结果

肿瘤和社会人口学特征均与生存独立相关。乳头状癌患者的10年相对生存率最高（0.98），其次是滤泡状癌患者（0.92）和髓样癌患者（0.80）。未分化肿瘤的10年相对生存率最低（0.13）。诊断时的分期和分化状态是每种组织学类型的强有力的独立预后因素。诊断时的晚期阶段对髓样癌来说是比其他组织学类型更强的预后因素。年龄增加与每种组织学类型的相对生存率降低相关。性别、婚姻状况和种族是显著但较弱的生存预测因素。