Buffington C A, Blaisdell J L, Kawase K, Komatsu Y
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210-1089, USA.
Am J Vet Res. 1997 Feb;58(2):146-9.
To investigate the effect of choreito consumption (500 mg/kg of body weight/d) on struvite crystal formation and signs of lower urinary tract disease (LUTD) in cats consuming a commercial canned diet with 0.5% added inorganic magnesium.
6 male and 6 female adult cats, all considered to be clinically normal on the basis of physical examination findings; results of CBC, serum biochemical analyses, urinalyses, and urine cultures; and freedom from urolithiasis on the basis of urethrocystoscopic (females) or urethrocystographic (males) findings.
Diets were fed for 12 weeks, or until appearance of signs of LUTD, including dysuria, hematuria, urine pH > 7.0, and severe struvite crystalluria. Presence of at least 2 of these signs was required for removal from study. Urine specimens were examined for electrolytes, struvite crystal content, and hematuria.
Results for urine variables were compared between groups at 4 weeks, because of reduction in cat numbers attributable to removal from study. Struvite crystal content of 24-hour urine specimens was significantly lower for cats fed the choreito-containing diet. Moreover, frequency and severity of hematuria were significantly decreased in cats fed the choreito-containing diet. Correlation between hematuria and struvite crystal content was not observed in either group. Additionally, all 6 cats fed the diet without choreito had been removed from study by day 58 because of signs of LUTD. Of the 6 cats fed the choreito-containing diet, 2 completed the 12-week study.
Choreito may be beneficial for relief of some signs of struvite-associated LUTD disease in cats.
研究食用choreito（500毫克/千克体重/天）对食用添加0.5%无机镁的商业罐装猫粮的猫的鸟粪石晶体形成及下尿路疾病（LUTD）体征的影响。
6只雄性和6只雌性成年猫，根据体格检查结果、全血细胞计数、血清生化分析、尿液分析和尿培养结果，均被认为临床正常；根据尿道膀胱镜检查（雌性）或尿道膀胱造影检查（雄性）结果，无尿石症。
喂食12周，或直至出现LUTD体征，包括排尿困难、血尿、尿液pH值>7.0和严重的鸟粪石结晶尿。从研究中剔除需要出现至少2种这些体征。对尿液样本进行电解质、鸟粪石晶体含量和血尿检查。
由于研究中剔除导致猫数量减少，在4周时比较了各组尿液变量的结果。喂食含choreito饮食的猫24小时尿液样本中的鸟粪石晶体含量显著较低。此外，喂食含choreito饮食的猫血尿的频率和严重程度显著降低。两组均未观察到血尿与鸟粪石晶体含量之间的相关性。此外，所有6只喂食不含choreito饮食的猫在第58天因LUTD体征被从研究中剔除。在6只喂食含choreito饮食的猫中，2只完成了12周的研究。
Choreito可能有助于缓解猫的鸟粪石相关LUTD疾病的一些体征。
