Piazza C, Gilardini Montani M S, Moretti S, Cundari E, Piccolella E
Department of Cellular and Developmental Biology, University La Sapienza, National Research Council of Italy (CNR), Rome.
J Immunol. 1997 Feb 15;158(4):1503-6.
To explore the possibility that CD4+ T cells, described to mediate the elimination of themselves or B lymphocytes, could also mediate the elimination of CD8+ T cells, we analyzed apoptotic phenomena in cocultures of CD4+ and CD8+ autologous T cell lines. The data show that CD8+ T cells were lysed by activated CD4+ helper T cells by a Fas/FasL-mediated mechanism. CD4+ T cells were not lysed by activated CD8+ T cells, although Fas and FasL were equally expressed and anti-Fas Abs induced apoptosis in both CD4+ and CD8+ T cell populations. The results allowed us to speculate that CD4+ T cells not only help CD8+ T lymphocytes to mature into effector killer cells and to sustain this function but can also limit their growth.
为了探究已被描述为介导自身或B淋巴细胞清除的CD4 + T细胞是否也能介导CD8 + T细胞的清除，我们分析了CD4 +和CD8 +自体T细胞系共培养中的凋亡现象。数据表明，活化的CD4 +辅助性T细胞通过Fas/FasL介导的机制裂解CD8 + T细胞。尽管Fas和FasL在CD4 +和CD8 + T细胞群体中均有表达且抗Fas抗体可诱导这两种细胞群体凋亡，但活化的CD8 + T细胞不会裂解CD4 + T细胞。这些结果使我们推测，CD4 + T细胞不仅有助于CD8 + T淋巴细胞成熟为效应杀伤细胞并维持该功能，还能限制其生长。
