Bigner D R, Goff J P, Faust M A, Burton J L, Tyler H D, Horst R L
Department of Animal Science, Iowa State University, Ames 50011, USA.
J Dairy Sci. 1996 Dec;79(12):2182-8. doi: 10.3168/jds.S0022-0302(96)76594-3.
The effect of metabolic alkalosis and acidosis on insulin response to glucose tolerance tests was determined for cows fed a high cation diet to induce a state of metabolic acidosis. The anion diet to induce a state of metabolic acidosis. The glucose tolerance test (500 mg of glucose/kg of BW infused i.v. over 10 min) caused a rapid increase in plasma glucose and insulin concentrations. Plasma glucose concentrations were highest, and plasma insulin concentrations were lowest, during metabolic acidosis. These results suggest that insulin secretion is impaired during metabolic acidosis, which may reduce tissue uptake of glucose. Correction of metabolic acidosis by oral administration of sodium bicarbonate prior to glucose tolerance testing increased blood pH and bicarbonate concentrations and partially restored insulin response to the glucose tolerance test. Interestingly, sodium bicarbonate also caused an elevation in plasma cortisol concentrations. We concluded that glucose utilization is altered in cows with metabolic acidosis. The correction of acidosis associated with diseases such as diarrhea and ketosis may improve the therapeutic benefit of glucose infusions used to treat these diseases.
对于采食高阳离子日粮以诱导代谢性酸中毒状态的奶牛，测定了代谢性碱中毒和酸中毒对葡萄糖耐量试验中胰岛素反应的影响。诱导代谢性酸中毒状态的阴离子日粮。葡萄糖耐量试验（500毫克葡萄糖/千克体重，静脉输注10分钟）导致血浆葡萄糖和胰岛素浓度迅速升高。在代谢性酸中毒期间，血浆葡萄糖浓度最高，而血浆胰岛素浓度最低。这些结果表明，代谢性酸中毒期间胰岛素分泌受损，这可能会减少组织对葡萄糖的摄取。在葡萄糖耐量试验前口服碳酸氢钠纠正代谢性酸中毒，可提高血液pH值和碳酸氢盐浓度，并部分恢复对葡萄糖耐量试验的胰岛素反应。有趣的是，碳酸氢钠还导致血浆皮质醇浓度升高。我们得出结论，代谢性酸中毒奶牛的葡萄糖利用发生了改变。纠正与腹泻和酮病等疾病相关的酸中毒可能会提高用于治疗这些疾病的葡萄糖输注的治疗效果。
