比较3小时葡萄糖耐量试验和2小时值在识别胎儿过度生长风险中的作用。

A comparison of the 3 H glucose tolerance test and the 2 H value in identifying risk for excessive fetal growth.

作者信息

Curet L B, Izquierdo L A, Gilson G J, Del Valle G O, Qualls C

机构信息

Department of Obstetrics and Gynecology, University of New Mexico-School of Medicine, Albuquerque, NM 87131, USA.

出版信息

J Matern Fetal Med. 1997 Jan-Feb;6(1):28-30. doi: 10.1002/(SICI)1520-6661(199701/02)6:1<28::AID-MFM5>3.0.CO;2-U.

DOI:10.1002/(SICI)1520-6661(199701/02)6:1<28::AID-MFM5>3.0.CO;2-U

PMID:9029381

Abstract

The objective of this study was to determine if the 2 h value of the glucose tolerance test (GTT) is as reliable as the complete GTT in identifying risk for excessive fetal growth. Five hundred eighty-eight patients underwent a 3 h oral GTT at 26-28 weeks' gestation. The 2 h value of the test was compared to the results of the GTT. The incidence of large for gestational age (LGA) infants was compared for patients who had an abnormal GTT or an abnormal 2 h value only. A normal 2 h value was associated with a normal GTT in 98.5% of cases, while an abnormal 2 h value was associated with an abnormal GTT in 70% of cases. An abnormal GTT was associated with a 22% incidence of LGA, while a 2 h value > or = 165 mgm/dl was associated with a 20% incidence of LGA. This difference was not statistically significant. A single 2 h value GTT is more cost-effective and as predictive as a complete 3 h GTT in identifying risk for excessive fetal growth.

摘要

本研究的目的是确定葡萄糖耐量试验（GTT）的2小时值在识别胎儿过度生长风险方面是否与完整的GTT一样可靠。588例患者在妊娠26 - 28周时接受了3小时口服GTT。将该试验的2小时值与GTT的结果进行比较。对仅GTT异常或仅2小时值异常的患者，比较巨大儿（LGA）的发生率。在98.5%的病例中，2小时值正常与GTT正常相关，而在70%的病例中，2小时值异常与GTT异常相关。GTT异常与22%的LGA发生率相关，而2小时值≥165mgm/dl与20%的LGA发生率相关。这种差异无统计学意义。在识别胎儿过度生长风险方面，单次2小时值GTT比完整的3小时GTT更具成本效益且预测性相同。