Isakova G K, Evsikov V I, Beliaev D K
Genetika. 1977;13(6):996-1007.
An analysis of aneuploidy and polyploidy in bone marrow cells of female minks of different genotype and age has shown that in young minks with unsatisfactory reproductive characteristics, and in old females, the frequency of aneuploid and polyploid cells is significantly higher as compared to that in minks having a good reproductive capacity. The increase in aneuploidy level takes place mainly in the form of hypoploidy, and an increase of the frequency of polyploid cells is accompanied by a parellel increase of the proportion of cells with a low degree of ploidy. A correlation between frequencies of appearance of aneuploid and polyploid cells in minks is observed (r = 0.69 +/- 0.27). On the basis of original and bibliographic data, a hypothesis on a genetically determined instability of karyotype in mutant minks is argumented.
对不同基因型和年龄的雌性水貂骨髓细胞中的非整倍体和多倍体进行分析后发现，生殖特征不佳的年轻水貂以及老年雌性水貂中，非整倍体细胞和多倍体细胞的频率显著高于具有良好生殖能力的水貂。非整倍体水平的增加主要以亚倍体形式出现，多倍体细胞频率的增加伴随着低倍体程度细胞比例的平行增加。观察到水貂中非整倍体细胞和多倍体细胞出现频率之间的相关性（r = 0.69 +/- 0.27）。基于原始数据和文献资料，论证了关于突变水貂中核型由遗传决定的不稳定性的假说。
