Dardis A, Saraco N, Mendilaharzu H, Rivarola M, Belgorosky A
Laboratory Research Unit, Hospital de Pediatria, Garrahan, Buenos Aires, Argentina.
Horm Res. 1997;47(2):85-8. doi: 10.1159/000185438.
Most XX male subjects present an anomalous translocation of the sex-determining region of the chromosome Y (SRY) gene from chromosome Y to chromosome X. Several explanations have been proposed for the differentiation of testicular tissue in the absence of SRY gene. A patient is presented in whom the SRY gene was absent in peripheral leukocytes but present in testicular tissue. This possibility should always be ruled out before diagnosing Y-negative XX maleness.
