Ito E, Kasai M, Toki T, Arai K, Yokoyama M
Department of Pediatrics, Hirosaki University School of Medicine, Japan.
Leuk Lymphoma. 1996 Nov;23(5-6):545-50. doi: 10.3109/10428199609054863.
Currently available data indicate that erythroid and megakaryocytic differentiation pathways are closely related to each other, and there may exist progenitor cells common to those two lineages may exist. Acute megakaryoblastic leukemia (AML-M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers. These blast cells express lineage-specific transcription factors such as GATA-1 common to these lineages and frequently express erythroid-specific mRNAs such as gamma-globin and erythroid delta-aminolevulinate synthase (ALAS-E), indicating that most of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes. These results suggest that blasts in M7 and TMD may correspond to progenitors of both erythroid and megakaryocytic lineages.
目前可得的数据表明，红系和巨核系分化途径彼此密切相关，可能存在这两个谱系共有的祖细胞。急性巨核细胞白血病（AML-M7）和唐氏综合征中的短暂性骨髓增殖性疾病（TMD）的特征是表达巨核细胞标志物的异常原始细胞快速生长。这些原始细胞表达这些谱系共有的谱系特异性转录因子，如GATA-1，并经常表达红系特异性mRNA，如γ-珠蛋白和红系δ-氨基乙酰丙酸合成酶（ALAS-E），这表明M7和TMD病例中的大多数原始细胞具有红系和巨核系表型。这些结果表明，M7和TMD中的原始细胞可能对应于红系和巨核系谱系的祖细胞。
