Sánchez S, Albornoz L, Bandi J C, Gerona S, Mastai R
Sección de Hígado, Hospital Italiano, Buenos Aires, Argentina.
Eur J Gastroenterol Hepatol. 1997 Jan;9(1):27-31. doi: 10.1097/00042737-199701000-00009.
To evaluate the influences of blood viscosity changes, mediated by a haemorheological agent, on splanchnic and systemic haemodynamic parameters in rats with cirrhosis due to chronic bile duct ligation.
Blood viscosity was measured using a cone-plate viscometer and whole blood filterability was determined by a filtration method. Cardiac index and portal venous inflow were measured using radioactive microspheres. Measurements were performed 30 min after double-blind administration of placebo or pentoxifylline (25 mg/kg, intravenously).
As compared with placebo, pentoxifylline-treated cirrhotic rats had a lower portal pressure (13.8 +/- 1.4 vs. 12.1 +/- 1.6 mmHg, P < 0.05) and blood viscosity at shear rates of 115/s (6.6 +/- 0.8 vs. 5.8 +/- 0.3 mPas, P < 0.05), associated with an improvement of whole blood filterability (45.0 +/- 12.9 vs. 20.0 = 3.9 s/ml, P < 0.01). Similar values of mean arterial pressure, cardiac index and portal venous inflow were observed in both groups. A significant correlation was found between portal pressure and blood viscosity at a shear rate of 115/s (r = 0.71, P < 0.01).
These results suggest that portal pressure can be modified by pentoxifylline in an experimental model of cirrhosis. These haemodynamic changes are associated with a lower blood viscosity and whole blood filterability. Pentoxifylline may be a new approach in the treatment of portal hypertension.
评估一种血液流变学药物介导的血液粘度变化对慢性胆管结扎所致肝硬化大鼠内脏和全身血流动力学参数的影响。
使用锥板式粘度计测量血液粘度，采用过滤法测定全血过滤性。使用放射性微球测量心脏指数和门静脉血流量。在双盲给予安慰剂或己酮可可碱（25mg/kg，静脉注射）30分钟后进行测量。
与安慰剂组相比，己酮可可碱治疗的肝硬化大鼠门静脉压力较低（13.8±1.4 vs. 12.1±1.6 mmHg，P<0.05），在剪切速率为115/s时血液粘度较低（6.6±0.8 vs. 5.8±0.3 mPas，P<0.05），同时全血过滤性得到改善（45.0±12.9 vs. 20.0 = 3.9 s/ml，P<0.01）。两组的平均动脉压、心脏指数和门静脉血流量值相似。在剪切速率为115/s时，门静脉压力与血液粘度之间存在显著相关性（r = 0.71，P<0.01）。
这些结果表明，在肝硬化实验模型中，己酮可可碱可改变门静脉压力。这些血流动力学变化与较低的血液粘度和全血过滤性相关。己酮可可碱可能是治疗门静脉高压的一种新方法。
