Yasunaga Y, Shinomura Y, Kanayama S, Miyazaki Y, Bonilla Palacios J J, Matsuzawa Y
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Ital J Gastroenterol. 1996 Oct-Nov;28(8):457-61.
It has been shown that serum pepsinogen I levels are correlated with maximal acid outputs and can be used as an indicator for parietal cell mass. In this study, the effect of Helicobacter pylori infection on the relationship between serum pepsinogen I levels and maximal acid outputs was investigated in 27 patients with Helicobacter pylori associated enlarged fold gastritis. Before treatment, serum pepsinogen I levels and maximal acid outputs were not significantly correlated. After eradication of Helicobacter pylori, a significant positive correlation was found between serum pepsinogen I levels and maximal acid outputs with a significant increase in pepsinogen I levels and a significant increase in maximal acid outputs. These results indicate that Helicobacter pylori infection distorts the relationship between serum pepsinogen I levels and maximal acid outputs by elevating the former and lowering the latter, and that serum pepsinogen I level after eradication of Helicobacter pylori may reflect parietal cell mass in patients with Helicobacter pylori associated enlarged fold gastritis.
研究表明，血清胃蛋白酶原I水平与最大胃酸分泌量相关，可作为壁细胞量的指标。在本研究中，对27例幽门螺杆菌相关性肥厚性胃炎患者，研究了幽门螺杆菌感染对血清胃蛋白酶原I水平与最大胃酸分泌量之间关系的影响。治疗前，血清胃蛋白酶原I水平与最大胃酸分泌量无显著相关性。根除幽门螺杆菌后，血清胃蛋白酶原I水平与最大胃酸分泌量之间发现显著正相关，胃蛋白酶原I水平显著升高，最大胃酸分泌量也显著增加。这些结果表明，幽门螺杆菌感染通过升高血清胃蛋白酶原I水平并降低最大胃酸分泌量，扭曲了两者之间的关系，且根除幽门螺杆菌后的血清胃蛋白酶原I水平可能反映幽门螺杆菌相关性肥厚性胃炎患者的壁细胞量。
