Ohye C, Shibazaki T, Hirato M, Inoue H, Andou Y
Department of Neurosurgery, Gunma University School of Medicine, Japan.
Stereotact Funct Neurosurg. 1996;66 Suppl 1:333-42. doi: 10.1159/000099733.
On the basis of our experiences with selective ventralis intermedius thalamotomy with microrecording, certain cases of tremor with Parkinson's disease (PD, six cases), intentional tremor (one case) and essential tremor (one case) were treated by Gamma Knife. In all cases, 140-150 Gy were irradiated using 4-mm collimators. Three different strategies were used. (1) Gamma thalamotomy as the primary surgical treatment. (2) As a secondary treatment, irradiation of the symmetric point of the contralateral selective thalamotomy. (3) Extension of the previous thalamotomy. For the first three cases (all PD), a special plug pattern (100 plugs) was used, but was not employed for the later cases. No acute untoward effects were noted, and overall there appeared to be a reduction in tremor. The time course of tremor reduction varied from case to case, from about 5-6 months to 1 year.
基于我们在采用微记录技术进行选择性丘脑腹中间核切开术方面的经验，对某些患有帕金森病震颤（6例）、意向性震颤（1例）和特发性震颤（1例）的患者进行了伽玛刀治疗。所有病例均使用4毫米准直器，给予140 - 150 Gy的照射剂量。采用了三种不同的策略。（1）伽玛丘脑切开术作为主要手术治疗方法。（2）作为辅助治疗，照射对侧选择性丘脑切开术的对称点。（3）扩大先前的丘脑切开术范围。前三例（均为帕金森病患者）使用了一种特殊的插塞模式（100个插塞），但后续病例未采用。未观察到急性不良影响，总体上震颤似乎有所减轻。震颤减轻的时间进程因病例而异，约为5 - 6个月至1年。
